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Xenical

It is possible to lose up to 30% of its own weight without diets, sports and health risks! This will help Xenical - an effective tool for losing weight. Learn how to take it and what cheaper alternatives can be replaced.

Many people want to lose weight, even those who do not really need it. But if you lose two or three kilograms, you can take up fitness or limit sweets in the diet, even the toughest diet can not cope with 20-30 kg of excess weight. And today there are a lot of such people: according to WHO statistics, every sixth inhabitant of the planet suffers from obesity.

Causes of increased body weight are diverse - not an active lifestyle, constant overeating, eating foods with high amounts of carbohydrates and fats. Endocrine diseases (hypothyroidism, diabetes), a genetic predisposition or a tendency to stress can also provoke the development of obesity.

In some cases, getting rid of the ill-starred kilograms, without resorting to surgical intervention, is possible only with the help of drugs. Existing weight loss products can be divided into three groups:

• reducing appetite;
• causing loose stools;
• blocking the absorption of fat.

The last type of drugs is Xenical, which takes 2nd place in the TOP 10 most popular drugs for weight loss.

The composition and effect of the drug

Xenical is produced by pharmaceutical companies F.Hoffmann-La Roche (Basel, Switzerland) and Rosh S.p.A. (Milan, Italy). The drug is available in the form of solid opaque capsule tablets of bluish-green color with white pellets (granules) inside. The capsules are labeled "XENICAL" on the case and "ROCHE" on the lid, and 21 pieces each are packaged in blisters. In a packing box of 1,2 or 4 blisters.

Basic and auxiliary substances

One capsule contains 120 mg of active substance orlistat, which is an inhibitor of gastrointestinal lipases, as well as excipients:

• microcrystalline cellulose - source of dietary fiber, filler;
• sodium starch glycolate - disintegrant (baking powder) of the superclass;
• Povidone - an adsorbent, a binder, ensures the stability of the shape of granules;
• sodium lauryl sulfate is a synthetic surfactant that promotes the rapid dissolution of the granules in the stomach;
• talc - baking powder, filler;
• fine titanium dioxide - dye.

The composition of the capsule shell includes gelatin and food dyes - titanium dioxide and indigo carmine.

Mechanism of action

When digesting food, triglycerides (fats) in the stomach and small intestines decompose to fatty acids, which are absorbed by the body and used as a source of energy. If the body gets more fat than it consumes in the process of life, their excess is deposited "for a rainy day" under the skin or on internal organs.

Orlistat is a specific blocker of gastric and pancreatic lipase. By forming strong covalent bonds with these enzymes, it deprives them of the ability to break down fats. Triglycerides are not absorbed into the systemic circulation, and “transit” pass through the gastrointestinal tract and are excreted in the feces. Not getting the right amount of "fuel", the body is forced to fill its deficit by adipocyte cells, set aside "in the depot." The effect of losing weight is based on the principle of spending such reserves of adipose tissue, that is, it is similar to the principles of fat-free diets.

According to clinical studies, with Xenical treatment, up to one third of the fat from food is excreted from the body unchanged. As a result of the two-month course of administration, the weight is reduced by 20-30%. The effect of the drug dose lasts 48–72 hours, the time for complete removal of orlistat residues from feces and urine is up to 5 days. Since orlistat practically does not enter the bloodstream, it does not affect the functioning of the internal organs and does not cause addiction syndrome. This means that if you take Xenical for a long time, you do not need to increase its dose.

Instructions for use

The main indication for the use of drugs containing orlistat is obesity (this diagnosis is made for people with a body mass index greater than 30). Xenical is also used in the complex therapy of diseases, one of the accompanying symptoms of which is overweight:

1. hyperlipidemia (lipid and lipoprotein metabolism);
2. hypertension;
3. diabetes;
4. atherosclerosis;
5. metabolic syndrome (deposition on the internal organs of the so-called visceral fat).

Dosage regimen and dosage

The recommended single dose of orlistat is 120 mg, that is, one capsule. The drug should be taken with water, every time with food, or after it, but no later than an hour. If the food does not contain fat, you can skip Xenical. It is recommended to use from 1 to 3 capsules per day, increasing the dose above the recommended therapeutic effect does not lead to an increase.

Additional recommendations

Due to the fact that orlistat prevents the absorption of not only fat, but also fat-soluble vitamins, they are recommended to be taken not earlier than one hour after eating. Usually, in order to eliminate micronutrient deficiencies, doctors together with Xenical prescribe a multivitamin complex containing:

• calciferol (vitamin D);
• retinol (vitamin A);
• provitamin beta carotene;
• tocopherol (vitamin E);
• vitamins of group K (phylloquinone, menahinon).

To achieve a better result, Xenical reception should be combined with the transition to a less calorie diet, which implies a restriction in the daily fat intake. Thus, when the content in the average daily diet is about 2000 kilocalories, the amount of fat in the composition of dishes should not exceed 65-70 g. Such “arithmetic” positively influences the outcome of treatment and reduces the risk of undesirable side effects.

Side effects

The results of clinical studies have shown that a side effect on Xenical is most often steatorrhea - an elevated fat content in the fecal mass. This is a direct consequence of the pharmacological action of the active substance, blocking the absorption of fat, a third of which passes through the stomach and intestines, without being digested.

Steatorrhea is manifested by oily secretions from the rectum, increased bowel movements, false urges, and in rare cases diarrhea or fecal incontinence. The likelihood of such side effects is much reduced when using a low-fat system of nutrition. However, even with significant violations of the stool, they appear only in the initial stages of treatment, in most cases - once.

More rare side effects include abdominal pain of a spastic nature, increased gas formation, flatulence. In clinical practice, isolated cases of the development of an allergic reaction to orlistat in the form of an itch or urticaria are described.

Contraindications

The instructions to Xenical indicated that this remedy for weight loss should be taken under the supervision of a physician - with diabetes, kidney stones, bulimia (a disease in which a person experiences a constant uncontrollable feeling of hunger). Direct contraindications are:

• age up to 18 years;
• pregnancy;
• breastfeeding period;
• gallbladder diseases (cholecystitis, cholestasis, biliary dyskinesia);
• malabsorption syndrome (impaired intestinal absorption of nutrients);
• body mass index is less than 25.

Synonyms and analogues

There are drugs that can replace the drug in case of its absence in pharmacies or too high cost, these are analogues and synonyms (generics). Analogs are drugs that have the same effect as the original drug, but acting on a different principle. They have a different composition and are distinguished by their effectiveness, side effects and a list of contraindications.

Generics - drugs with the same active ingredient as the original. They may have their own names, differ in excipients, and be produced in other dosage forms: tablets, capsules, pills, powders, granules, mixtures, etc... As the cost of development and clinical trials the generic manufacturer does not carry, such drugs as usually cost much less unique.

The synonyms of Xenical based on orlistat include:

• Alai (Germany);
• Xenistat (India);
• Orlikel (India);
• Orlip (Georgia);
• Symmetra (India);
• Orsoten and Orsoten slim (Slovenian and Russian production);
• Xenalten (Russia).

The price range for these drugs is quite wide, but, in any case, the cost of analogs is lower than the cost of the original. Thus, the Slovenian Orsoten (84 capsules) costs 2300 rubles, the same Orsoten or Xenalten produced in Russia - from 900 to 2000 rubles.

Among the Xenical analogues, Reduksin (manufactured by Avista, Russia), and Goldline (manufactured by RANBAXY LABORATORIES, India) are the most popular. The active substance in them is sibutromin hydrochloride, which has an effect on the center of saturation located in the hypothalamus. Weight loss occurs by reducing food intake, as the feeling of fullness comes faster and lasts longer.

Can you cope with the obesity epidemic?

The world is increasingly talking about the epidemic of obesity. According to estimates by experts of the World Health Organization since 1975, the number of people suffering from obesity has more than tripled. Especially fast growth rate is observed in developing countries. Now about 10% of the global population is obese, and this, according to data for 2016, is 108 million children and 604 million adults.

In 2016, for the first time in its history, mankind faced a situation where overweight people on the planet became more than people with underweight, and the death rate from the effects of overweight and obesity exceeded the death rate due to hunger.

Why does this happen, why mankind is rapidly growing heavy? The thing is that most of us move less and less often and choose more often semi-finished products or fast food. And there is an explanation for this: the pace of modern life is so fast that people just don’t want to spend time cutting salad or cooking soup. It is much easier to have a snack on the run with a sandwich or order pizza home - which, by the way, can be done right on the way from work, without interrupting your chat with friends in a smartphone.

Specialists from the Bill and Melinda Gates Foundation are a key factor contributing to weight gain, they believe it is the nature of food that has changed in recent years, and not the lack of exercise. They believe that sweet soda and inexpensive semi-finished foods rich in fats, carbohydrates and flavor enhancers stimulate the development of obesity much more than a sedentary lifestyle.

A team of researchers from Cambridge (University of Cambridge) even speaks about the “obesity environment” that has recently formed around us, filled with ready-made food stores, fast-food businesses and kiosks where you can buy take-away food.

It is important to remember that the development of obesity and problems caused by obesity can be prevented. To do this, you need to reconsider your lifestyle: walk more, get enough sleep, be less nervous, more often be in the fresh air.

Even minimal physical activity is better than its complete absence, the researchers are sure, urging all of us not to neglect sports. But you need to change and nutrition. So, for example, in order to reduce the amount of food consumed, which gives a quick, but short-term saturation, it is worth increasing the proportion of protein in the diet.

Alla V. Shilina, Herbalife expert, recommends that each main meal should include 25-30 g of protein. This amount is contained in 100 g of meat, 150 g of fish or cottage cheese, in one portion of the Formula 1 protein shake from Herbalife.

You need to eat fractional: in addition to breakfast, lunch and dinner - the main meals, do not forget about snacks, and you need to snack not with chocolates or crackers, but with healthy foods that not only satisfy hunger, but also give long-term satiety. These can be fruit with yogurt, nuts, eggs, or Herbalife protein bars.

Advice to change the diet and lead a more mobile lifestyle may seem simple and therefore not very effective. But they really help to avoid gaining extra pounds and getting rid of those already gained.

Lose weight without dieting: 22 simple but effective tips

It is not by chance that nutritionists repeatedly remind us that the best diet is proper nutrition. Lose weight without dieting is easier than you think, but eating tasty and satisfying, but losing weight at the same time is quite possible. The most important thing is to stick to a healthy diet and turn a healthy lifestyle into a habit that will become as usual for you as brushing your teeth in the morning and 10 pages of a new book in the evenings.

Ready to take action right now? Below are twenty-two tips to help you lose weight without dieting and no significant restrictions. Sounds like magic, but, nevertheless, it really works.

Eat slowly

If you are used to lunch and dinner "like a meteor," try to slow down, because perhaps because of the speed you eat more than you need. And, as a result, gain extra pounds, instead of getting rid of them. In the first few weeks, the timer on the phone will help: set it to 20 minutes, and make sure that the meal takes up all this time. Take a sip of water and chew each piece thoroughly.

Sleep enough

WebMD portal cites a researcher from the University of Michigan (University of Michigan), who admitted that an extra hour of sleep each day helped him lose 7 kilograms per year. This scenario shows that when you do not get enough sleep, the cognitive processes slow down, so the brain loses the ability to quickly send signals of hunger and satiety.

Consume more vegetables

Try to make fresh or grilled (which ones are better for frying - read here) the vegetables are always on your table. In addition to the obvious utility, they help to visually increase the size of the dish, so that you don’t really feel that you have eaten too little to get enough. Add to this a high water content, which will help maintain optimal hydration and significantly improve skin condition. Good advice: cook vegetables without oil, and season with lemon juice and fresh greens.

Do not forget the soup

Add chicken broth or light vegetable soup to the menu, and you won't notice how those extra pounds will leave you forever. Soup is especially useful at the beginning of a meal, as it slows down digestion, restrains appetite and prevents you from attacking harmful snacks. In addition, if you are sick, broth is strategically important for faster recovery and relief of cold symptoms. But beware of creamy cream soups that can boast of high fat and calories.

Bet on whole grains

Whole grain cereals, such as brown rice, barley, oats, buckwheat, and wheat, help to be filled with fewer calories, and at the same time reduce the level of "bad" cholesterol in the blood. But, best of all, extremely attractive products are now made from whole grains. For example, waffles and muffins, the base for pizza and pasta, as well as "white" whole wheat bread. The main thing - carefully study the information on the packaging.

Discard bacon

Refuse to add bacon to your morning scrambled eggs or turkey and bacon sandwich for lunch - and 100 calories are gone. It seems quite a bit, but in a week you will get rid of the extra 700 calories, and in two you will get over 1500 calories, which is comparable to the “cost” of a small cake with berries. By the way, less nutritious tomatoes, grainy mustard or soft cheese with fresh herbs can make the dish more fragrant.

Modify your favorite dishes

Do you like pizza? There is no reason to refuse it! Just come to the choice of options wisely: ask to make pizza on thin dough, olive oil and using low-fat cheese. It is unlikely that the pizzeria will refuse to fulfill the order, but even if, keep in mind that today the consumer can and should choose from a huge number of manufacturers. So, maybe it's time to find a new place that you can call “yours”.

Reduce the amount of sugar

Replace one sweet drink (for example, a glass of soda with plain water), and you will avoid 10 tablespoons of sugar. The scale is impressive, isn't it? And if you add lemon, mint or frozen strawberries to the water, the aroma will be even better, and the pleasure will be even greater than from the usual cola. What is the danger of sweet soda? First of all, the fact that liquid sugar is not fixed by our body as a full meal. So with one bottle you can get up to 450 calories that go unnoticed. Another thing is also interesting: according to studies, those who prefer sweets or chocolates over soda instead of soda, gain on average less weight.

Use tall and narrow glass

Another diethack life hack - replace your regular glass with a tall and narrow one, and your weight will decrease without a diet. Because so you will drink 25-30% less juice, soda, wine or any other drink. How it works? Brian Wansink, PhD, Cornell University (Cornell University), explains that visual deception can reconfigure the brain. The texts showed that even experienced bartenders poured more drink in a low and wide glass than in a tall and narrow one.

Limit alcohol

Agree, there are situations when you can’t, and probably don’t want to give up a fun event with an alcoholic accompaniment. But alcohol blocks the brain's ability to report satiety and hunger, and in large quantities destroys this mechanism altogether, so be very careful. Nutritionists advise to follow the scheme: an alcoholic drink, a glass of water, an alcoholic drink, two glasses of water, an alcoholic drink. To keep yourself in hand was easier, remember that alcohol contains more calories per gram than carbohydrates or protein.

Drink green tea

Green tea - the most correct option for those who seek to get rid of extra pounds. Some researchers suggest that it can temporarily activate the “calorie-burning engine” through the action of phytochemicals called catechins. At least, in any case, you get a delicious refreshing drink without a ton of calories.

Practice yoga

According to a study published in the Journal of the American Dietetic Association, women who practice yoga weigh less on average than those who do other sports. Scientists suggest this may occur because yoga aims at harmony not only of the body, but also of thought. That is why people who practice yoga together with it practice meditation. This allows them to be calmer, more effectively resist stress and attentive to food.

Eat at home

Eat homemade meals at least five days a week. A survey conducted by Consumer Reports, showed that this is one of the main habits of "successful slimming." Besides the fact that you finally learn to cook your favorite lasagna and pesto in your own kitchen, this approach has a lot of other bonuses. For example, significant savings and the ability to re-think any dish for themselves. Well, and, of course, so you can control the amount of sugar, salt and fat consumed, which will benefit your waist.

Catch a "pause in food"

Most people have a natural "pause in food" - the moment when they put a fork or spoon in a plate for a couple of minutes. Watch this moment, as it means that you can finish the meal right now. Nutritionists say that this is a signal of the fullness (but not overcrowding) of your stomach. And, unfortunately, almost all of us miss it.

Chew Mint Cud

Chew sugarless gum with a strong mint flavor when you feel like you are about to eat a burger and fries. Dinner after work, chatting at a party, watching TV or surfing the net - these are some dangerous scenarios for a thoughtless snack. Mint in chewing gum interrupts most flavors and aromas, so that "harmful" food will no longer be so attractive. Caution: Use this advice only in extreme situations, so as not to provoke the production of gastric juice when you are hungry, and not harm the digestive system.

Take a smaller plate

Professor Brian Uansink as a result of a series of experiments found that people eat more and more often overeat when they use large plates. Just choose a plate in two times less, and you will get rid of 100-200 calories per day and from 7-9 extra pounds per year. It is noteworthy that the volunteers who took part in the food experiment did not feel hungry with the reduction of the plate, and most of them simply did not notice this.

Eat small meals

The best habit of slender people, according to Consumer Reports polls, is that they eat a little, but often. In other words, five meals a day is the norm from which they recede only in critical situations. And it only seems to you that it is difficult. Adherents of such a food system admit that after a week of frequent meals you will not be able to do otherwise, you will feel so comfortable.

Try the 80/20 rule

Many celebrities, among them the top model Gisele Bundchen, admit that they can be kept in shape and not get out of their favorite food through the 80/20 system. Its essence boils down to the fact that you have to choose a convenient period (day or week), after which make 80% of the food during this time be healthy foods, and 20% are not the healthiest, but incredibly tasty.

Order food correctly

Restaurant meals are known to contain more calories and fat than you expect. So keep in mind several strategies in a restaurant that nutritionists say will help you keep portions under control: share a meal with a friend, order a starter as a main course, choose something from the children's menu, or add a main dish with a whole salad but a few leaves of green salad.

Choose red sauce

Choosing a sauce for pasta or baked potatoes, stop at the red options, it will be salsa, adzhika, bordolez or red pesto. The fact is that tomato-based sauces, as a rule, contain fewer calories and much less fat than creamy and, especially, mayonnaise sauces. But remember that the portion size still matters.

Sometimes become a vegetarian

Eating vegetarian meals is a great habit for losing weight. No, no one forces you to give up meat completely, especially considering that it can be harmful to health. However, today in every second burger and in every first Italian cafe you can find hamburgers with a bean or lentil cutlet and pasta with spinach and dried tomatoes, the taste characteristics of which will pleasantly surprise you.

Pamper yourself

When you have learned to do without soda for at least five days out of seven, or are used to coping with overeating with apple slices, and not chips, praise yourself. You were able to make even a simple, but at the same time very difficult thing - to tune in to proper nutrition. Now everything will be easier and simpler, we know that for sure. However, do not forget about food indulgences, which are necessary in order to reduce the risk of overeating to a minimum. Go for a pedicure, buy a new dress or allow yourself a piece of cheesecake. Because psychological health and a positive attitude are important for a healthy relationship with food almost more than all of the above.